Caffeine supplementation increases mortality in female Drosophila melanogaster without reproductive or metabolic impairment
نویسنده
چکیده
1015-1028; Nagaraju, G., and R. Scully 2007, DNA Repair 6:1018-1031; Pellegrini, L., and A. Venkitaraman 2004, Trends Biochem. Sci. 29: 310-316; Pellegrini, L., D.S. Yu, T. Lo, S. Anand, M. Lee et al. 2002, Nature 420: 287-293; Rabinow, L., 2002, Cancer Invest. 20: 531-56; Shivji, M.K., O.R. Davies, J.M. Savill, D.L. Bates, L. Pellegrini et al. 2006, Nucleic Acids Res. 34: 40004011; Venkitaraman, A.R. 2002, Cell 108: 171-182; Wang, W., 2007, Nat. Rev. Genet. 8: 735-748; Warren, M., A. Smith, N. Partridge, J. Masabanda, D. Griffin et al. 2002, Hum. Mol. Genet. 11: 841851; Xia, F., D.G. Taghian, J.S. DeFrank, Z.C. Zeng, H. Willers et al. 2001, Proc. Natl. Acad. Sci. USA 98: 8644-8649.
منابع مشابه
Aconitase and Developmental EndPointsasEarly IndicatorsofCellularToxicity Induced by Xenobiotics in Drosophila Melanogaster
Background: In this study, the toxicity of the different xenobiotics was tested on the fruit fly Drosophila melanogaster model system. Methods: Fly larvae were raised on food supplemented with xenobioticsat different concentrations (sodium nitroprusside (0.1-1.5 mM), S-nitrosoglutathione (0.5-4 mM), and potassium ferrocyanide (1 mM)). Emergence of flies, food intake by larvae, and pupation h...
متن کاملConcentration dependent effect of morphine, aspirin, capsaicin and chili pepper hydro alcoholic extract on thermal and chemical pain model in fruit fly (Drosophila melanogaster)
Introduction: Pain research using animal models is related to ethical concerns, so invertebrates and insects have been recommended by researchers. In the present study, the nociceptive and antinociceptive effects of capsaicin, aspirin, morphine and chili extract were examined using fruit fly (Drosophila melanogaster) as an alternative for rodent pain model. Methods: Stage 3 of larvae and ad...
متن کاملCytochrome P450-Dependent Metabolism of Caffeine in Drosophila melanogaster
Caffeine (1, 3, 7-trimethylxanthine), an alkaloid produced by plants, has antioxidant and insecticide properties that can affect metabolism and cognition. In vertebrates, the metabolites derived from caffeine have been identified, and their functions have been characterized. However, the metabolites of caffeine in insects remain unknown. Thus, using radiolabelled caffeine, we have identified so...
متن کاملCocoa confers life span extension in Drosophila melanogaster.
Cocoa is thought to be an excellent source of antioxidants. Here, we investigated the effects of cocoa supplementation on Drosophila melanogaster life span under different oxidative stress conditions. Our results illustrate that a moderate supplementation of cocoa under normoxia increases the average life span, whereas, at higher concentrations, average life span is normal. Under hyperoxia or i...
متن کاملToxicological Evaluation of a New Lepidopteran Insecticide, Flubendiamide, in Non-Target Drosophila melanogaster Meigen (Diptera: Drosophilidae)
Background: Flubendiamide, comparatively a new pesticide designed to eradicate lepidopteran insect pests is known to have low risk to birds, mammals, fish, algae, honey bees, non-target arthropods, earthworms, soil macro- and micro-organisms, non-target plants as well as sewage treatment organisms; however, the risk assessment for aquatic invertebrates from metabolite could not be finalized wit...
متن کامل